Insight by Health and Wellness
Artificial sweeteners and other additives are not physiologically inert because they alter gut microbes and taste preferences and some (e.g., saccharin, sucralose) can provoke blood‑glucose responses rather than acting as harmless calorie-free substitutes.
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Non‑caloric sweeteners can increase hunger and weight because sweet taste signals and conditioned responses trigger cephalic‑phase insulin and appetite changes even without calories, leading to higher subsequent food intake.