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Fat hiding inside skeletal muscle drives insulin resistance and is linked to Alzheimer’s disease and cardiovascular disease.
A lean woman with average body fat had elevated glucose, insulin, and triglycerides. Her muscle mass was nearing sarcopenia.
Low muscle mass can produce prediabetes-like metabolic signs even when body fat is not abnormally high.
Exercise improves muscle quality even when body composition, muscle mass, and fat mass stay unchanged.
There is no such thing as sedentary healthy muscle. It must contract and move to use fats and other fuels.
DEXA does not show muscle quality. CT or MRI are currently the main ways to assess it.
Protein above the 0.8-gram RDA does not automatically become fat. The body first oxidizes it, uses it, or turns it into glucose.
Protein is harder to overeat than carbohydrates or fats because the body spends more energy processing it.
Interleukin 6 is the best-known myokine, yet science understands only about 5% of myokines.
Muscle is the body's primary site for disposing of glucose from consumed carbohydrates, not merely a movement system.
Skeletal muscle amount and quality may predict mortality and health outcomes better than body-fat percentage.
Muscle-derived myokines support fat burning and carbohydrate metabolism beyond the exercise session.
Movement has its own public-health crisis: an exercise deficiency syndrome.
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