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Gene-expression data alone misses immune-cell identity and lineage changes revealed by 3D genome mapping and epigenetic signatures.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
Immune remodeling in the hippocampus appears to begin during midlife, potentially connecting aging with persistent inflammation linked to neurodegenerative disease.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
Researchers used single-cell analyses of postmortem hippocampal tissue from 40 neurologically healthy adults aged 20 to 95.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
Why resident microglia disappear with age, and whether their replacement drives Alzheimer’s or other age-related neurological conditions, remains unknown.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
Aging is linked to fewer cells maintaining the blood-brain barrier, potentially weakening the boundary controlling bloodstream entry into the brain.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
The apparent replacement of resident microglia challenges the assumption that these embryonically derived cells self-renew throughout life.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
From roughly age 50 to 75, the hippocampus gradually loses microglia, its main immune cells.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
As resident microglia decline, they appear to be replaced by cells with stronger inflammatory signals and blood-derived immune traits.
Science DailyScientists discover a hidden brain shift that begins around age 50
@science
Regular caffeine intake increases the number of D2 and D3 dopamine receptors.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Epinephrine creates neural energy: the desire and capacity to move and act, not merely calories.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
L-tyrosine sensitivity varies wildly: some people tolerate 2 g, while others respond to 100 mg or nothing.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Four neuromodulators dominate motivation, energy, mood, and learning: dopamine, epinephrine, serotonin, and acetylcholine.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Caffeine does more than wake you through adrenaline and lower adenosine. It also increases dopamine receptor number and efficacy.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
L-tyrosine substantially increases dopamine within 15–45 minutes, with effects tapering after roughly 30 minutes to two hours.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Build a dopamine toolkit, not a dopamine pile: test tools individually, then adapt them to sleep, travel, diet, and daily demands.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Neuromodulators act quickly and slowly. Your baseline state determines how acute interventions affect your brain.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Tryptophan sits upstream of serotonin synthesis the way tyrosine sits upstream of dopamine synthesis.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Dopamine, epinephrine, acetylcholine, and serotonin are shared ingredients behind changes in focus, energy, motivation, and relaxation.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Early-day sunlight exposure to the eyes increases dopamine receptor availability, making dopamine more effective for motivation and mood.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Mucuna pruriens can spike dopamine sharply, then leave you facing a substantial crash.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Deliberate cold exposure is the most potent behavioral tool described for sustained dopamine increases, with dopamine and epinephrine reinforcing each other.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Adrenal-gland epinephrine cannot cross the blood-brain barrier. The brain produces its own in the locus coeruleus.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Receiving gratitude produces a stronger serotonin-related effect than giving it. Watching gratitude exchange can activate the observer’s serotonergic circuits.
Andrew HubermanControl Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials
@science
Mitochondria may influence the whole organism and subjective experience, but the chamber study included only 20 people.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
Mitochondria create molecules that switch genes on and off, linking the genome to changing environments.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
The amount and nature of energy mitochondria transform may shape human experience and drive health or disease.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
People with mitochondrial disease reported more fatigue and stress, while metabolic abnormalities correlated with anxiety.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
The proposed link between mitochondria and consciousness remains speculative and has not been demonstrated.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
The mitochondrial health index measures energy-transformation capacity by extracting mitochondria from tissue and quantifying their molecular contents.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
Energy-flow ideas remain unusual in academic science, but strong data can make unconventional hypotheses harder to dismiss.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
Mitochondria may act like circuit resistors, constraining energy flow into a range compatible with health.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
Mitochondria differ between organs and even neighboring cells, producing distinct energy outputs and biochemical functions.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
Changing mitochondrial condition alters responses to mental stress, even when organisms experience the same physical discomfort.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
People with rare mitochondrial diseases burned 180 extra calories daily and used 15% more energy, even during sleep.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
A 2025 map found human-brain mitochondria vary across regions and among cell types within the same organ.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
In anxious or depressed rats, increasing mitochondrial output restored neuronal function and reduced anxiety-like behavior.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
A commercially available supplement matched the behavioral and neuronal benefits of experimentally boosting mitochondrial output in anxious or depressed rats.
Rachel NuwerMartin Picard’s Mitochondrial Theory of Mind
@science
Researchers can identify intrinsic brain networks without tasks by tracking regions that covary during arbitrary activities.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
When speech motor planning fails, the brain’s language network becomes a promising target for communication interfaces.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Language regions coordinate as an intrinsic network, remaining functionally organized even during nonlanguage activities.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Language tasks reveal a distributed, primarily left-lateralized network spanning temporal and inferior frontal regions.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Does the brain contain language-selective tissue, or does language recruit domain-general systems? Neuroscience still debates it.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Language networks differ in location and perhaps strength, but experience and anatomy remain difficult to disentangle.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Language is processed by many brain regions working in parallel, not a relay race of isolated computations.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Mapping language in the brain could lead to tools that read intended speech when articulation is impaired.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
“The old gray house” sounds normal, but “the gray old house” reveals that word order carries structure.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Conversation is a real-time exchange of internal meaning models, with both minds updating as speech unfolds.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Correlating brain activity during the same story aligns language networks across people despite anatomical differences.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Some patients can formulate messages while losing the motor planning required to speak them aloud.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
One fMRI voxel can look uniform from afar while hiding sharply different neuronal populations inside.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Neurons stacked inside one cortical column can prefer completely different speech properties.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Conversation is not a one-way pipeline. Two brains continuously update and push each other’s models of meaning.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Brain-computer interfaces can decode speech movements, but decoding the meaning someone intends remains unsolved.
Wu Tsai Neurosciences Institute, StanfordA new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain
@science
Understanding OCD’s neural circuitry and treatment failures helps people make informed choices and support others with the disorder.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Mindfulness helps people with OCD mainly by improving engagement with cognitive behavioral therapy homework, not by directly relieving symptoms.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
OCD ranks approximately seventh among the most debilitating illnesses of all kinds, not merely mental disorders.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
A drug’s symptom relief does not prove its targeted biological system causes the psychiatric disorder.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
The Yale-Brown Obsessive-Compulsive Scale is the most commonly used assessment for OCD.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Nutraceutical research still needs lower-dose trials and tests combining them with behavioral, prescription, and brain-stimulation treatments.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
OCD involves a highly active cortico-striatal-thalamic loop connecting perception, action control, and sensory relay.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Anxiety connects OCD obsessions to compulsions, producing threat-like thoughts and bodily arousal without clear present danger.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
The most intriguing TMS question is whether it works better alongside medication or cognitive behavioral therapy.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
OCD can consume the time needed for work, relationships, education, exercise, conversation, and a rich life.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Exposure-based CBT teaches people to tolerate anxiety instead of escaping it through compulsions.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Exposure and ritual prevention break the learned link between intense anxiety and compulsive action.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
OCD exposure therapy approaches feared thoughts progressively, then prevents the associated ritual in a supportive clinical setting.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Compulsions bring brief relief, then strengthen the obsession and trap people in a self-perpetuating loop.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Exposure-based CBT interrupts OCD by removing the brief anxiety relief that normally reinforces compulsive behavior.
Andrew HubermanThe Science & Treatment of Obsessive Compulsive Disorder (OCD) | Huberman Lab Essentials
@science
Your caretakers, relationships, thoughts, language, and environments customize your nervous system.
Andrew HubermanHow to Focus to Change Your Brain
@science
People blind from birth can develop substantially sharper touch and hearing than typical sighted people.
Andrew HubermanHow to Focus to Change Your Brain
@science
Passive entertainment consumes limited acetylcholine, epinephrine, and dopamine that could support learning and personally enriching activities.
Andrew HubermanHow to Focus to Change Your Brain
@science
A productive learning bout lasts about 90 minutes: spend 5 to 10 minutes warming up, then sustain focus for about an hour.
Andrew HubermanHow to Focus to Change Your Brain
@science
Effortfully extracting information from text or audio engages plasticity-related cholinergic systems more strongly than watching an entertaining movie.
Andrew HubermanHow to Focus to Change Your Brain
@science
Visual focus is the primary route for deploying attention and plasticity neurochemicals when alertness is present but not excessive.
Andrew HubermanHow to Focus to Change Your Brain
@science
During early development, sensory inputs compete for brain space. Deprived inputs can be taken over by active ones.
Andrew HubermanHow to Focus to Change Your Brain
@science
Once consolidated, learning can persist essentially permanently unless a later process actively unlearns it.
Andrew HubermanHow to Focus to Change Your Brain
@science
Early sensory loss leaves more cortical territory available for reassignment while the developing brain remains highly plastic.
Andrew HubermanHow to Focus to Change Your Brain
@science
The brain learns threats in one painful encounter, like touching a hot stove, because rapid plasticity protects you.
Andrew HubermanHow to Focus to Change Your Brain
@science
Alertness is necessary but insufficient for learning. Being awake during passive exposure, even listening during sleep, does not create learning.
Andrew HubermanHow to Focus to Change Your Brain
@science
The Kennard principle says brain injuries generally heal better and faster when they happen earlier in life.
Andrew HubermanHow to Focus to Change Your Brain
@science
Acetylcholine helps you react to a starting gun and contract muscles, making it relevant to sprint performance.
Andrew HubermanHow to Focus to Change Your Brain
@science
Blinking does more than lubricate your eyes. It resets your perception of time and space.
Andrew HubermanHow to Focus to Change Your Brain
@science
Without alertness driven by epinephrine, focused learning cannot properly begin.
Andrew HubermanHow to Focus to Change Your Brain
@science
For difficult changes, identify several motives: attraction, fear of failure, love, or avoiding shame.
Andrew HubermanHow to Focus to Change Your Brain
@science
Attention releases neuromodulators that mark circuits ready to change. It opens neuroplasticity’s first gate, but does not guarantee change.
Andrew HubermanHow to Focus to Change Your Brain
@science
Plasticity followed attention, not stimulation alone: tactile training changed touch systems when attention focused there instead of on an auditory tone.
Andrew HubermanHow to Focus to Change Your Brain
@science
Experience alone does not reliably change the brain. High-precision attention makes experience plasticity-relevant.
Andrew HubermanHow to Focus to Change Your Brain
@science
Experience alone does not rewire the brain. Lasting plasticity requires chemicals that strengthen or weaken active connections.
Andrew HubermanHow to Focus to Change Your Brain
@science
Repetition changes the brain most effectively when paired with focused attention and plasticity-enabling neurochemical conditions, not passive exposure.
Andrew HubermanHow to Focus to Change Your Brain
@science
As attention and learning capacity become more limited with age, selectivity lets people invest more resources in what matters.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Your brain uses overlapping processes to remember the past and imagine the future, building tomorrow from past experiences.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Protect memory two ways: strengthen well-learned skills and keep exposing yourself to genuinely new experiences.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Frailty and dependence in later life are not necessarily negative. With the right structure, relying on others can help.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Effort and progress activate the brain’s reward systems, making meaningful hard work feel rewarding.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Selective optimization with compensation means doing one favorite hike regularly instead of chasing every possible activity.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
In a lineup, identifying a face can replace the original memory with the identified person’s face and features.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Moderation adapts to context: one desired cup of coffee can fit, while excessive daily consumption may not.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Healthy forgetting updates memory: discarding an old hotel room number prevents interference with the new one.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Want to remember names? Retrieve each name repeatedly after meeting someone instead of trusting one initial association.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Aging well means pursuing meaningful challenges while also recovering and knowing when to ease off the gas.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Superagers may be distinguished not only by health, but by resilience after serious adversity.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
After age 40, most people feel about 20% younger than their actual age.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Routine driving can run with so little conscious oversight that you miss turns without noticing the journey.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Previewing a performance room can raise arousal while reducing unfamiliarity and increasing comfort when the event begins.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Mistakes direct attention to uncertain details, making correction and later learning more effective.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Learning gets stronger when retrieval feels challenging. Making material maximally easy can make it easier to forget.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Feeling certain you know something is not proof you know it. Metacognition is noticing that gap.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Try to retrieve or reproduce information before reviewing the correction. Even inaccurate attempts improve learning.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
Self-testing exposes the gap between what you know and what you need to learn. Rereading and highlighting expose it less clearly.
Andrew HubermanHow to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
@science
In traditional Ghanaian etiquette, the left hand is for dirty tasks, while the right handles eating, paying, and social interactions.
Quanta MagazineWhy Am I Left-Handed?
@science
Only about 10% of humans are left-handed, yet left-handers are overrepresented among presidents, artists, musicians, and elite athletes.
Quanta MagazineWhy Am I Left-Handed?
@science
Microtubules may transport signaling molecules asymmetrically inside spinal-cord progenitor cells, amplifying tiny imbalances into neural differences.
Quanta MagazineWhy Am I Left-Handed?
@science
Some genes linked to left-handedness are also linked to schizophrenia, dyslexia, and autism, where left-handedness is more common.
Quanta MagazineWhy Am I Left-Handed?
@science
Tubulin variants might weaken the initial rightward bias, letting random fluctuations occasionally give the left side an advantage.
Quanta MagazineWhy Am I Left-Handed?
@science
A plausible developmental model must explain handedness’s partial heritability, strong rightward bias, and substantial randomness.
Quanta MagazineWhy Am I Left-Handed?
@science
Combat advantages alone may not explain why humans preserve such a stable 10–90 split between left- and right-handers.
Quanta MagazineWhy Am I Left-Handed?
@science
A 2026 review found that people are stabbed more often on the left, and left-sided stabbings are more often fatal.
Quanta MagazineWhy Am I Left-Handed?
@science
Large-scale genetic studies identified about 40 variants that each slightly increase left-handedness likelihood. No single gene explains it.
Quanta MagazineWhy Am I Left-Handed?
@science
The biggest genetic surprise: most handedness-associated variants are tubulin genes, which build cellular structures and transport components.
Quanta MagazineWhy Am I Left-Handed?
@science
Fetal arm-movement asymmetry appears around 10 weeks after conception, before the brain connects to the limbs.
Quanta MagazineWhy Am I Left-Handed?
@science
Chronic stress harms adaptation when continuous exposure prevents recovery and downregulation. Too little stress can also block adaptation.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Healthy food access depends on more than money: cooking knowledge and physical access create barriers too.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Individual prevention cannot address every major dementia determinant. Socioeconomic deprivation requires structural change.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Shingles studies mostly involved people in their late seventies or eighties, so they cannot show whether vaccination in the fifties prevents later dementia.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Across training, learning, and practice, one third of sessions feel excellent, one third average, and one third terrible.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Alzheimer’s disease accounts for approximately 60–80% of dementia cases.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Sleep is the boundary for tolerable stress: when stress erodes sleep, the overall load needs adjustment.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Resistance exercise increases IGF-1, a molecule important for white-matter development and maintenance across the lifespan.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
The strongest evidence supports reaching non-deficiency. Whether exceeding that threshold improves health remains uncertain.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
In COSMOS, a basic multivitamin providing about 100% of the recommended daily allowance was associated with improved cognition in older adults.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
High-intensity exercise releases myokines and lactate. Lactate enters the brain and may stimulate BDNF, supporting neuroplasticity.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Reaction time worsens from roughly the 30s and declines faster after 60. Processing speed stays stable until around 60.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Hard cognitive work is sustainable only in bounded periods. An uninterrupted eight-hour day overestimates intense focus.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
After concussion, preventing overheating matters more than aggressively forcing the body into hypothermia.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Flow is the maximal expression of a complex learned skill at the edge of current capability.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Older-adult studies commonly examine resistance training with several exercises, repeated sets, and sessions multiple times weekly.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Randomized trials show novel language, movement, musical, and music-theory activities improve cognitive function in older adults.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
In older adults, 40-minute brisk walks three times weekly for a year were associated with increased hippocampal volume, VO2 max, and circulating BDNF.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
In ACTIVE, processing-speed training with boosters at years one and three was associated with lower dementia risk 20 years later.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
Six months of high-intensity interval training produced hippocampal benefits that remained five years after the intervention ended.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
@science
In older adults, six months of Norwegian 4×4 training preserved hippocampal structure for five years after training ended.
Andrew HubermanAccelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood

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