Scientists discover a hidden brain shift that begins around age 50

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@science· The Brain
Researchers used single-cell analyses of postmortem hippocampal tissue from 40 neurologically healthy adults aged 20 to 95.
@science· The Brain
As resident microglia decline, they appear to be replaced by cells with stronger inflammatory signals and blood-derived immune traits.
@science· The Brain
The apparent replacement of resident microglia challenges the assumption that these embryonically derived cells self-renew throughout life.
@science· The Brain
Why resident microglia disappear with age, and whether their replacement drives Alzheimer’s or other age-related neurological conditions, remains unknown.
@science· The Brain
From roughly age 50 to 75, the hippocampus gradually loses microglia, its main immune cells.
@science· The Brain
Aging is linked to fewer cells maintaining the blood-brain barrier, potentially weakening the boundary controlling bloodstream entry into the brain.
@science· The Brain
Immune remodeling in the hippocampus appears to begin during midlife, potentially connecting aging with persistent inflammation linked to neurodegenerative disease.
@science· The Brain
Gene-expression data alone misses immune-cell identity and lineage changes revealed by 3D genome mapping and epigenetic signatures.

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